Rap1 and Rap2 antagonistically control endothelial barrier resistance.
Rap1 and Rap2 are closely related proteins of the Ras family of small G-proteins.Rap1 is well known to regulate cell-cell adhesion.Here, we have analysed the effect of Rap-mediated signalling on endothelial permeability using electrical impedance measurements of HUVEC monolayers and subsequent determination of the barrier resistance, which is a mea